Symptoms and causes of Varicose Veins

Varicose veins are more common in women than in men. Some of the most common factors are the following: 

  • Heredity 

  • Pregnancy

  • Obesity

  • Menopause

  • Aging

  • Prolonged Standing

  • Leg Injury

  • Abdominal Straining

Varicose veins are unlikely to be caused by crossing the legs or ankles. Less commonly, varicose veins can be due to other causes, such as post phlebitic obstruction or venous and arteriovenous malformations. 

Pelvic Vein Reflux (PVR) In The Development Of Varicose Veins

More recent research has shown the importance of pelvic vein reflux (PVR) in the development of varicose veins. Hobbs showed varicose veins in the legs could be due to ovarian vein reflux and Lumley and his team showed recurrent varicose veins could be due to ovarian vein reflux. Whiteley and his team reported that both ovarian and internal iliac vein reflux causes leg varicose veins and that this condition affects 14% of women with varicose veins and 20% of women who have had vaginal delivery and have leg varicose veins. In addition, evidence suggests that failing to look for and treat pelvic vein reflux can be a cause of recurrent varicose veins. There is increasing evidence for the role of incompetent Perforator veins (or "perforators") in the formation of varicose veins and recurrent varicose veins.

Hyperhomocysteinemia And Varicose Veins

Varicose veins could also be caused by hyperhomocysteinemia in the body, which can degrade and inhibit the formation of the three main structural components of the artery: 

  • Collagen 

  • Elastin 

  • Proteoglycans

Homocysteine permanently degrades cysteine disulfide bridges and lysine amino acid residues in proteins, gradually affecting function and structure. Simply put, homocysteine is a "corrosive" of long-living proteins, i.e. collagen or elastin, or lifelong proteins, i.e. fibrillin. These long-term effects are difficult to establish in clinical trials focusing on groups of existing artery decline. Klippel-Trenaunay syndrome and Parkes-Werber syndrome are relevant for differential diagnosis.Another cause is chronic alcohol consumption due to the vasodilatation side effect in relation to gravity and blood viscosity.